Cardiovascular Diseases

Cardiovascular disease or Cardiovascular diseases refers to the class of diseases that involve the heart or blood vessels (arteries and veins). While the term technically refers to any disease that affects the cardiovascular system (as used in MeSH), it is usually used to refer to those related to atherosclerosis (arterial disease). These conditions have similar causes, mechanisms, and treatments. In practice, Cardiovascular disease is treated by cardiologists, thoracic surgeons, vascular surgeons, neurologists, and interventional radiologists, depending on the organ system that is being treated. There is considerable overlap in the specialties, and it is common for certain procedures to be performed by different types of specialists in the same hospital.

There are many types of Cardiovascular diseases such as High Blood Pressure (Hypertension), Angina, Arrhythmia etc.

Most countries face high and increasing rates of Cardiovascular disease. Each year, heart disease kills more Americans than cancer..

It is the number one cause of death and disability in the United States and most European countries (data available through 2005). A large histological study (PDAY) showed vascular injury accumulates from adolescence, making primary prevention efforts necessary from childhood.

By the time that heart problems are detected, the underlying cause (atherosclerosis) is usually quite advanced, having progressed for decades. There is therefore increased emphasis on preventing atherosclerosis by modifying risk factors, such as healthy eating, exercise and avoidance of smoking.

For Treatment of various Cardiovascular diseases following types of medicines are used.

Sr Sub Group Generic Prescription (Rx) Drugs Generic Prescription (Rx) Drugs In Treatment Of Common Brand Name for Generic Prescription (Rx) Drugs
1. HYPER ACIDITY, REFLUX, ULCERS BISMUTH SUBCITERATE Benign Gastric & Duodenal Ulceration Mertonidazole,Tetracycline
1.  ANTIARRHYTHMIC DRUGS   VERAPAMIL   Control of Ventricular & supraventricular arrhythmaias   Isoptin, Verelan, Calan, Bosoptin, Covera-HS 
     QUINDINE   Management of cardiac arrhythmias   Quinaglute, Quinidex 
     DISOPYRAMIDE   Mgt of supraventricular & ventricular arrhythmias   Norpace, Rythmodan 
     AMIODARONE   Control of Ventricular and supraventricular arrhythmaias including those associated
w/Wolff-Prakinson-white
syndrome 
 Pacerone,Cordrone,
Aratac, Arycor 
     SOTALOL HCL   Management of
supraventricular arrhythmias 
 Betapace,Sotalex,
Sotacor 
     MEXILETINE   Treatment of ventricular arrhythmias   Mexitil 
     ADENOSONE   Treatment of Paroxysmal supraventricularTachycardia;
differentil diagnosis of
superaventricular Tachycardias 
 Adenosine,Detoxamin 
     ATENOLOL   Intravenou: emergency
treatment of Cardiac arrhythmias 
 Tenormin 
     DILITIAZAM   Intravenous: Mgt of cardiac arrhythmias   Progor,Herben,Attiazen,
Cardizem, Dilatam,Tiazac,
Dilcardia 
     ISMOLOL   Intravenous: rapid temporary
control of ventricular rate in superventricular arrhythmias 
Brevibloc
     LIDOCAINE   Intravenous:treatment of ventricular
arrhythmias in advanced cardiac life support for cardiac arrest due to ventricular fibrillation and pulseless ventricular Tachycardia 
Lidocaine , Xylocaine
     METOPROLOL   Treatment of cardiac arrhthmias  Lopressor, Toprol-XL,
Seleken Minax, Metrol, Betaloc, Neobloc, Corvitol.
     PROPAFENONE   Paroxysmal atrial fibrillation/flutte ;
Paroxysmal superaventricular Tachycardia associated w/ disabling symptoms 
Propafenone
     PROPRANOLOL   Intravenous: Emergency treatment
of cardiac arrhythmias 
Inderal,Inderal LA,Propranolol Hydrochloride, Propranolol Intensol,
Apo-Propranolol
     S- ATENOLOL    Apo-Atenolol,Novo-Atenolol,
Tenormin
2.  ANTI HYPERTENSIVE DRUGS   AMILORIDE + HYDROCHLOTHIAZIDE   Mild to moderate Hyper
Tension (HTN) 
Moduretic,Apo-Amilzide ,
Gen-Amilazide, Moduret,
Nu-Amilzide
     AMLODIPINE   Mangement of Hyper
Tension (HTN) 
 Dailyvasc,Norvasc,Istin,
Perivasc 
     AMLODIPINE +
ATENOLOL 
 Hyper Tension (HTN)  Tenoretic,Apo-Atenidone,
Tenoretic
     AMLODIPINE +
BENAZEPRIL 
 Hyper Tension(HTN)    Lotrel 
     AMLODIPINE +
ENALAPRIL 
 Refractory HTN,HTN
w/ coexisting congestive failure 
 
     AMLODIPINE +
LISINOPRIL 
 Mild to moderate Hyper
Tension (HTN) not responding
to monotherapy 
 
     AMLODIPINE +
LOSARTAN 
 Mangement of Hyper Tension (HTN)   
     ATENOLOL   Mangement of Hyper Tension(HTN)   Tenormin 
     ATENOLOL+
CHLOTHALIDONE 
  Hyper Tension (HTN)   
     ATENOLOL +
NIFEDIPINE 
 Hyper Tension(HTN);Angina   
     BENAZEPRIL   Treatment of  Hyper Tension (HTN)  Lotensin
     BENIDIPINE   Treatment of Hyper Tension (HTN)   Coniel 
     BISOPROLOL   Mangement of Hyper Tension
(HTN); management of Angina
Pectoris 
 Concor,Zebeta,Monocor 
     CANDESRTAN  Management of Hyper Tension(HTN) Blopress,Atacand,Amias,
Ratacand
     CAPTOPRIL   Treatment in Hyper Tension(HTN)   Capoten 
     CAPTOPRIL + HYDRO
CHLOROTHIAZIDE 
 Hyper Tension(HTN)  Capocard plus 
     CARVEDILOL   Management of Hyper Tension(HTN)   Coreg,Dilatrend,
Eucardic ,Carloc 
     CELIPROLOL   Management of  Hyper Tension(HTN);Management of Angina Pectoris   Cardem,Celectol,Celipres,
Celol, Cordiax,Dilanorm 
     CLONIDINE   Treatment in Hyper Tension(HTN)   Catapres,Dixarit 
     CLONIDINE + CHLOROTHIAZIDE   Treatment in Hyper tension(HTN)   
     CLOPAMIDE   Hyper Tension(HTN)  Brinaldix
     DOXAZOSIN   Management of Hyper Tension(HTN)   Candura 
     ENALAPRIL   Management of Hyper Tension(HTN)   Renitec,Vasotec 
   

ENALAPRIL+HYDRO
CHLOROTHIAZIDE
 

 Management of Hyper Tension(HTN)   
     FELODIPINE   Management of Hyper Tension(HTN)  Plendil
     FOSINOPRIL   Management of Hyper Tension(HTN)   Monopril 
     FUROSEMIDE   Management of Hyper Tension(HTN)   Lasix 
     FUROSEMIDE +
AMILORIDE 
 Mild to moderate HTN and where Diuresis is required but
conservation of K & Mg is important 
 
     HYDRO-
CHLOROTHIAZIDE 
 Management of Hyper Tension(HTN)   Aquazide,Microzide,
Esidrex, Oretc 
     IMIDAPRIL   Management of Hyper Tension(HTN)   Tanatril 
     INDAPAMIDE   Management of Hyper Tension(HTN)   Natrilix 
     IRBESARTAN   Management of Hyper Tension (HTN)   Aprovel, Karvea, Avapro 
     LABETALOL   Management of Hyper Tension (HTN)   Normodyne,Tradate,
Normozyle 
     LACIDIPINE   Management of Hyper Tension (HTN)   Lacipil, Moteus 
     LERCANIDIPINE   Management of Hyper Tension (HTN)   Zamidip 
     LISINOPRIL   Management of Hyper Tension (HTN)   Prinivel, Zestril 
     LOSARTAN   Management of Hyper Tension (HTN)   Lozaar 
    METHYLDOPA   Management of Hyper Tension (HTN)  Aldomet,Dopamet,
Novomedopa 
     METOLAZONE   Management of Hyper Tension (HTN)    Zaroxolyn,Mykrox 
     METOPROLOL   Management of Hyper Tension (HTN)  Lopressor,Selokeen,Minax,
Corvitol,Neobloc
     NEBIVOLOL  Management of Hyper Tension (HTN)  Nebilet,Nebicard,Nubeta,
Lobivan,Bystolic 
     NIFEDEPINE  Management of Hyper Tension(HTN)   Adalat,Nefedical,Procardia 
    PERINDOPRIL   Management of Hyper Tension(HTN)   Coversyl,Aceon 
    PRAZOSIN   Management of Hyper Tension(HTN)   Minipress,Vasoflex,Hypovase
     PROPRANOLOL   Management of Hyper Tension(HTN)  Avlocardyl
     RAMIPRIL  Management of Hyper Tension(HTN) Tritace,Ramace 
     RESERPINE  Management of Hyper Tension(HTN)  Ecoplanet,Serpazide 
     S-AMLODIPINE   Management of Hyper Tension(HTN)   
     S-AMLODIPINR+
NEBIVOLOL 
 Management of Hyper Tension(HTN)  
     S-ATENOL   Management of Hyper Tension(HTN)  
     TELMISARTAN   Management of Hyper Tension(HTN) Pritor,Kinzal,Micardis,Telday,
Teleact-D
    TERAZOSIN   Management of Hyper Tension(HTN)  Hytrin 
     TORASEMIDE   Management of Hyper Tension(HTN)  Luprac,Demadix 
3.  ANTI
HYPERTENSIVE
DRUGS 
 TRANDOLAPRIL  Management of Hyper Tension(HTN)   Mavik 
    TRIAMTERENE   Oedema  Dyrenium 
    VALSARTAN   Management of Hyper Tension(HTN)  Diovan,Valtam,Valzaar 
    VERAMPRIL  Management of Hyper Tension(HTN)  Isoptin,Veretan,
CalanBosoptin, Cover-HS
4. ANTIANGINALS
& CORONORY VASOLIDATORS 
AMLODIPINE  Management of Hyper Tension(HTN) & Angina Pectoris;treatment of stable Angina and Prinzmetal's Angina   Dailyvasc,Norvasc,Istin,
Perivasc 
     AMLODIPINE +
ATENOLOL 
 Angina,Chronic Unstable Vasospastic & Unstable   
     ATENOLOL   Management of Angina Pectoris  Tenormin
    ATENOLOL +
NIFEDIPINE 
HTN ;Angina  
     BENIDIPINE  Management of Angina Pectoris  Coniel 
    BISOPROLOL   Management of Hyper Tension (HTN) & Angina Pectoris   Concor,Zebeta,Monocor 
    CELIPROLOL   Management of Hyper Tension (HTN) & Angina Pectoris   Cardem,Celectol,Celipres,
Celol,Cordiax, Dilanorm 
    DILTIAZEM  Management of Angina Pectoris   Progor,Herben,Attiazem,
Cardizem, Dilatam,Tiazac,
Dilcardia 
     FELODIPINE   Management of Angina Pectoris  Plendil 
     GLYCERYL
TRINITRATE 
 Longterm management of Stable
Angina 
 Nitroglycerine 
    ISOSORBIDE
DINITERATE 
 Longterm management of Stable
Angina 
Dilatrate,Isordil, Cedocard,
Sorbitrate,Isoket
     ISOSORBIDE
MONONITERATE 
 Longterm management of Stable
Angina & Heart Failure 
 Imdur,  Chemydur
     METOPROLOL  Management of Angina Pectoris   Lopresor,Toprol XL,Selokeen,Metrol,Betaloc
     NIFEDIPINE  Management of Angina Pectoris  Adalat, Nefedical, Procardia
    OXYFEDRINE  Management of Angina Pectoris   
    PENTAERYTHRITYL
TETRANITERATE
Management of Angina Pectoris  
     PROPRANOLOL  Pheochromocytoma   Avlocardyl 
     TRANDOLAPRIL     Mavik 
     NICORANDIL  Management of Angina Pectoris  Ikorel,Dancor,Aprior ,Sigmart
5 VASODILATORS   CILOSTAZOL  Treatment of intermittent Claudication Pletal
     CINNARIZINE   Treatment of peripheral vascular
disorder
Stugeron,Stunarone
     CYCLANDELATE  Management of cerebrovascular &
peripheral vascular disorders 

Cyclospasmol

     ISOXSUPRINE   Treatment of Cereberal and
peripheral vascular disease 
Vasodilan,Voxsuprine
    PENTOXIFYLLINE   Treatment of  peripheral vascular
disease 
Trental
     XANTINOL
NICOTINATE 
 Mgt of cerebrovascular & peripheral vascular disorders   All Pro 
6. VASOCONSTRICTORS EPHEDRINE   Treatment of Diabetic neuropathic
oedema 
Ephedrine Sulfate
     MEPHENTERMINE  Maintenance of BP in hypotensive
states 
Adipex P,Anoxine-AM, Ionamin ,Duromine, Fastin, Mirapront , Obephen ,Obermine , Obestin-30,Phentremene , Phentrol , Phenterex, Phentromin ,Pro-Fast SA , Redusa, Panbesy,Phentermine Trenker , Obenix ,Oby-Trim,
Teramine , Zantryl , Sinpet (MX),Supremin (PH , Umine (NZ), ,Weltmine (KP)
7.  ANTI COAGULANTS
THROMBOLYTICS &
ANTIPLATLET DRUGS 
 ABCIXIMAB   Stablisation in patients w/ unstable Angina  ReoPro
    ACENOCOUMAROL  Mgt of Thromboembolic disorders  Sintrom and Sinthrome
    ALTEPLASE   Intravenous: it initiates local fibrinolysis & dissolution of clots by binding to fibrin in a
thrombus and the fibrin-bound plasminogen is converted to plasmin 
Cathflo Activase 
    ASPIRIN +
CLOPIDOGREL 
 Secondary Prophylaxis of vascular events  
    ASPIRIN+
DIPYRIDAMOLE 
 Secondary Prophylaxis of vascular events   
    CLOPIDOGREL   Prophylaxis in Thromboembolic disorders including MI,peripheral arterial disease &
Stroke 
Plavix
     DALTEPARIN
SODIUM 
 Treatment of established deep-vein thrombosis & plumonary embolism  Fragmin
    DIPYRIDAMOLE  Prophylaxis of Thromboembolism following cardiac valve replacement  Apo-Dipyridamole FC  
     ENOXAPARIN  Treatment of Deep-Vien Thrombosis  LOVENOX,Clexane
    GENSPARIN  Treatment of Deep-Vien Thrombosis   
    HEPARIN   treatment of Venous Thromboembolism   Heparin
     NADROPARIN
CALCIUM
Prophylaxis of venous thromboembolism
during surgical procedures 
Fraxiparine
    PARNAPARIN   Prophylaxis of venous thromboembolism
during surgical procedures 
Fluxum 
    REVIPARIN
SODIUM 
 Prophylaxis of venous thromboembolism
during surgical procedures 
Clivarin
    STREPTOKINASE   Treatment of acute MI  Streptase
    TICLOPDINE  Prevention of Thrombotic strokes  Ticlid 
     TIROFIBAN  Mgt of unstable Angina  Aggrastat
    UROKINASE  Treatment of periphera Arterial Thromboembolism  Abbokinase,Abbokinase
Open-Cath 
    WARFARIN   Prevention & treatment of venous thromboembolism   Coumadin, Jantoven,
Marevan, and Waran 
8. HAEMOSTATICS/
ANTIHAEMORRHAGICS
 AMINOCAPROIC
ACID 
 Treatment & prophylaxis of haemorrhage  Amicar 
     APROTININ  Treatment of Haemorrhage   
    ETHAMSYLATE  Mgt of short-term blood loss in Menorrhagia   
    HEMOCOAGULASE   Haemostatic in primary & secondary & post operative in internal & external Haemorrhage  
     SOMATOSTATIN Treatment of GI haemorrhage  Somatostatin 
    TRANEXAMIC ACID   Short term mgt of haemorrhage  Cyklokapron ,Transamin
9. INOTROPIC AGENTS,
DRUGS USED IN CHF
AMRINONE   Short term mgt of Heart failure   Inocor 
    CAPTOPRIL   Treatment of Heart failure   Capoten 
    CAPTOPRIL+ HYDRO
CHLOROTHIAZIDE 
 Treatment of Heart failure   
    DIGOXIN   Mgt of supraventricular arrhythmias atrial fiberillation& heart failure    Lanoxin, Digitek, Lanoxicaps 
     DOBUTAMINE   Mgt of acute Heart failure   
     DOPAMINE  Treatment of acute heart failure & MI   Dobutamine 
     ENALAPRIL  Mgt of heart failure  Renitec and Vasotec 
     ENALAPRIL+ CHLOROTHIAZIDE  Mgt of heart failure  
     LISINOPRIL  Mgt of heart failure   Prinivil , Tensopril,
Zestril 
    PERINDOPRIL   Mgt of heart failure  Coversyl, Aceon 
     RAMIPRIL  Mgt of heart failure  Tritace , Altace
10.  DIURETICS  ACETAZOLMIDE   Induction of Diuresis   
    AMILORIDE + HYDRO
CHLOROTHIAZIDE 
 Induction of Diuresis   
     CHLORTALIDONE   Treatment of Oedema associated w/ heart failure   Clorpres 
     CLOPAMIDE  OEDEMA   Adurix
    FUROSEMIDE   Treatment of Oedema associated w/ heart failure   Lasix
    HYDRO
CHLOROTHIAZIDE 
Treatment of Oedema associated w/ heart failure  Hydrochlorothiazide 
    TORASEMIDE  Oedema of renal origin   Demadex
11.  LIPID LOWERING
AGENTS 
ATORVASTATIN  Treatment of Hypercholesterolaemia   Lipitor 
    ATORVASTATIN +
EZETIMIBE 
 Treatment of Hypercholesterolaemia   
     ATORVASTATIN + FENOFIBRATE  Mixed Dyslipidaemia   
    BEZAFIBRATE   Treatment of all forms of Hyper Lipoproteinaemias  Bezalip  
       Treatment of Hypercholesterolaemia
(Type IIA & II B). Hyper
Lipoproteinaemias 
Baycol, Lipobay 
     EZETIMIBE   Primary Hyper Cholesterolamia,
homozygous familial hyper
cholesterolaemia (phytosterolaemia)
 Vytorin and Inegy 
     FENOFIBRATE  Treatment of Hyper Lipoproteinamias
(Type II A,II B,III,IV,V) 
Tricor ,Trilipix , Lipofen, Lofibra, Lipanthyl , Lipidil, Fenogal
    GEMFIBROZIL   Treatment of Hyper Lipoproteinamias
(Type II A,II B,III,IV,V) 
Lopid, Jezil , Gen-Fibro
     LOVASTATIN   Treatment of Hypercholesterolaemia
(Type IIA & II B). Hyper Lipoproteinaemias 
 Mevacor ,Rovacor
     NICOTINIC ACID  Treatment of Hyper Lipidaemia   Niacin , Niacor,  Nicolar , Nicotinex, Elixir, Slo-Niacin, Novo-Niacin 
     PRAVASTATIN   Treatment of Hypercholesterolaemia
(Type IIA & II B). Hyper Lipoproteinaemias 
 Pravachol , Selektine
     ROSUVASTATIN   Primary hyper holesterolaemia
(Type II A including hterozygous failial hyper cholesterolaemia (type II B),including familial hyper cholesterolaemia as an adjunc t to diet and  Exercise 
Crestor 
    SIMVASTATIN  Treatment of Hypercholesterolaemia
(Type IIA & II B). Hyper Lipoproteinaemias
 Zocor, Simlup, Simcard,
Simvacor,

A. Antihypertensive:
Antihypertensives are a class of drugs that are used in medicine and pharmacology to treat hypertension (high blood pressure). There are many classes of antihypertensives, which—by varying means—act by lowering blood pressure. Evidence suggests that reduction of the blood pressure by 5-6 mmHg can decrease the risk of stroke by 40%, of coronary heart disease by 15-20%, and reduces the likelihood of dementia, heart failure, and mortality from Cardiovascular Disease. Examples of Antihypertensives are as follows:


Brand Names Generic Prescription (Rx) Drugs
cozaar
losartan
norvasc
amlodepine
vaseretic
enalapril + hydrochlorothiazide
aceon
perindopril
lopressor
metoprolol
toprol xl
metoprolol tartrate
altace
ramipril
lotrel
amlodepine
lotensin
benazepril hydrochloride
cordrone
amiodarone
tenoretic
atenolol,chlorthalidone
lotensin
benazepril hydrochloride
zebeta
bisoprolol
calan,isoptin
verampil
cilexetil,atacand
candesartan
adalat,procardia
nifeepine
hydrochlorothiazide
hydrochlorothiazide
diovan
valsartan
tenormin
atenolol
vasotec
enalapril
avapro
irbesartan
moduretic
amiloride hcl/hydrochlorothiazide
norvasc
amlodipine besylate
capoten
captopril
cardizem
dilitazem
cardura
doxazosin mesylate
catapres
clonidine
combipres
clonidine,chlorthaidone
esidrix,hydrodiuril,oretic
hydrochlorothiazide
vaseretic
enalapril maleate + hctz
plendil
felodipine
hytrin
terazosin
inderal
propranol
lozol
indapamide
lotensin
benazepril hydrochloride
prinivil,zestril
lisionopril
prizide
lisinopril/hydrochlorothazide
minipress prazosin

B. Anti Anginals:
Anti Anginals used to treat chest pain which is due to ischemia (a lack of blood and hence oxygen supply) of the heart muscle, generally due to obstruction or spasm of the coronary arteries (the heart's blood vessels). Examples of Anti Anginals are as follows:

Brand Names Generic Prescription (Rx) Drugs
persantine
dipyridamole
ismo,monoket,imdur
isosorbide mononiterate
adalat,procardia
nifeepine
isordil,sorbitrate
isosorbide diniterate

C. Anticoagulant:
An anticoagulant is a substance that prevents coagulation; that is, it stops blood from clotting. A group of pharmaceuticals called anticoagulants can be used in vivo as a medication for thrombotic disorders. Examples of Anticoagulant are as follows:

Brand Names Generic Prescription (Rx) Drugs
coumadin
warfarin sodium
plavix
warfarin sodium

D. Antiarrhythmic:
Antiarrhythmic agents are a group of pharmaceuticals that are used to suppress fast rhythms of the heart (cardiac arrhythmias), such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation.
Examples of Antiarrhythmic are as follows:

Brand Names Generic Prescription (Rx) Drugs
norpace
disopyramide

E. Antithrombolytics or Fibrinolytics:
Antithrombolytics or Fibrinolytics are used in medicine to dissolve blood clots in a procedure termed thrombolysis. They limit the damage caused by the blockage of the blood vessel. Examples of Antithrombolytics or Fibrinolytics are as follows:

Brand Names Generic Prescription (Rx) Drugs
norpace
disopyramide

F.Diuretic:
A diuretic is any drug that elevates the rate of bodily urine excretion (diuresis). There are several categories of diuretics. All diuretics increase the excretion of water from the body, although each class of diuretic does so in a distinct way. Examples of Diuretics are as follows:

Brand Names Generic Prescription (Rx) Drugs
lasix
furosemide

G. Inotropic
Agents used in CHF: An inotrope is an agent which alters the force or energy of muscular contractions. Negatively inotropic agents weaken the force of muscular contractions. Positively inotropic agents increase the strength of muscular contraction.
Most commonly, the inotropic state is used in reference to various drugs that affect the strength of contraction of heart muscle (myocardial contractility). Examples of Inotropic Agents used in CHF are as follows:

Brand Names Generic Prescription (Rx) Drugs
lanoxin digoxin

H. Lipid-Lowering Agents:
Lipid lowering agents are used as a part of a total plan including diet and exercise to reduce blood lipids in an effort to reduce the morbidity and mortality of atherosclerotic Cardiovascular disease and its sequelae. Examples of Lipid-Lowering Agents are as follows:

Brand Names Generic Prescription (Rx) Drugs
lipitor atorvastatin
zocor simvastatin
tricor fenofibrate
lopid gemfibrozil
mevacor lovastatin

I. Vasodilator:
A vasodilator is a drug or chemical that relaxes the smooth muscle in blood vessels, which causes them to dilate. Dilation of arterial blood vessels (mainly arterioles) lead to a decrease in blood pressure. Examples of Vasodilator are as follows:

Brand Names Generic Prescription (Rx) Drugs
pletal cilostazol