Endocrine Disorders

There are many types of Endocrine Disorders such as Adrenal disorders, Glucose homeostasis disorders, Metabolic bone disease, Pituitary gland disorders, Parathyroid gland disorders, Sex hormone disorders, Thyroid disorders, Tumours of the endocrine glands, Autoimmune polyendocrine syndromes, Incidentaloma etc.

Endocrinology is a branch of medicine dealing with disorder of the endocrine system and its specific secretions called hormones, the integration of developmental events such as proliferation, growth, and differentiation (including histogenesis and organogenesis) and the coordination of metabolism, respiration, excretion, movement, reproduction, and sensory perception depend on chemical cues, substances synthesised and secreted by specialized cells.

Endocrinology is concerned with the study of the biosynthesis, storage, chemistry, and physiological function of hormones and with the cells of the endocrine glands and tissues that secrete them.

The endocrine system consists of several glands, in different parts of the body, that secrete hormones directly into the blood rather than into a duct system. Hormones have many different functions and modes of action; one hormone may have several effects on different target organs, and, conversely, one target organ may be affected by more than one hormone.

It is  classified as a hormone, a chemical must be produced by an organ, be released (in small amounts) into the blood, and be transported by the blood to a distant organ to exert its specific function. There are also paracrine mechanisms (chemical communication between cells within a tissue or organ), autocrine signals (a chemical that acts on the same cell), and intracrine signals (a chemical that acts within the same cell).A neuroendocrine signal is a "classical" hormone that is released into the blood by a neurosecretory neuron.

Hormones act by binding to specific receptors in the target organ. A receptor has at least two basic constituents:

  1. a recognition site, to which the hormone binds
  2. an effector site, which precipitates the modification of cellular function.
Adrenal Disorders:
  • Adrenal insufficiency
  • Addison's disease
  • Congenital adrenal hyperplasia (adrenogenital syndrome)
  • Mineralocorticoid deficiency
  • Conn's syndrome
  • Cushing's syndrome
  • adrenogenital syndrome
  • Pheochromocytoma
  • Adrenocortical carcinoma
  • GRA/Glucocorticoid remediable aldosteronism
Glucose Homeostasis Disorders:
  • Diabetes mellitus
  • Hypoglycemia
  • Idiopathic hypoglycemia
  • Insulinoma
Metabolic Bone Disease:
  • Osteoporosis
  • Osteitis deformans (Paget's disease of bone)
  • Rickets and osteomalacia
Pituitary Gland Disorders:
  • Diabetes insipidus
  • Hypopituitarism (or Panhypopituitarism)
  • Pituitary tumors
  • Pituitary adenomas
  • Prolactinoma (or Hyperprolactinemia)
  • Acromegaly, gigantism
  • Cushing's disease
Parathyroid gland disorders:
  • Primary hyperparathyroidism
  • Secondary hyperparathyroidism
  • Tertiary hyperparathyroidism
  • Hypoparathyroidism
  • Pseudohypoparathyroidism
Sex Hormone Disorders:
  • Disorders of sex development or intersex disorders
  • Hermaphroditism
  • Gonadal dysgenesis
  • Androgen insensitivity syndromes
  • Hypogonadism
  • Gonadotropin deficiency
  • Kallmann syndrome
  • Klinefelter syndrome
  • Ovarian failure
  • Testicular failure
  • Turner syndrome
  • Disorders of Gender
  • Gender identity disorder
  • Disorders of Puberty
  • Delayed puberty
  • Precocious puberty
Menstrual function or fertility disorders :
  • Amenorrhea
  • Polycystic ovary syndrome
Thyroid disorders:
  • Goiter
  • Hyperthyroidism and Graves-Basedow disease
  • Hypothyroidism
  • Thyroiditis
  • Thyroid cancer
Tumours of the endocrine glands not mentioned elsewhere
  • Multiple endocrine neoplasia
  • MEN type 1
  • MEN type 2a
  • MEN type 2b

Autoimmune polyendocrine syndromes
Incidentaloma - an unexpected finding on diagnostic imaging, often of endocrine glands
Sr Sub Group Generic Prescription (Rx) Drugs Generic Prescription (Rx) Drugs In Treatment Of Common Brand Name for Generic Prescription (Rx) Drugs
1. GONADOL HORMONE & RELATED DRUGS ALLYLESTRENOL Mgt of threatened miscarriage  
    BROMOCRIPTINE Hypogonadism;Galactorrhea;Infertility Parlodel
         
    DANAZOL Treatment of benegin breast disorders Danocrine
         
    DYDROGESTERONE Mgt of recurrent miscarriage Duphaston
    ESTROGENS Menapausal HRT;replacement therapyfor primary ovarian failure;Palliative treatment of Prostatic Carcinoma: Intravenous;  Acute treatment of uterine bleeding Oestrogen
    ETHYL ESTRADIOL HRT;Female Hypoestrogensim  
         
    HUMAN MENOPAUSAL GNADOTROPHINES Female infertility,Infertility in male,In vitro fertilisation procedures or other assisted conception techniques  
         
    HYDROXY-PROGESTERONE CAPROATE Mgt of recurrent miscarriage  
         
    MEDROXY-PROGESTERONE Mild to moderate Endometriosis;Menorrhagia;Secondary Amenorrhoea;as Progesterone component in menapausal HRT  
         
    MESTEROLONE Androgen defeciency disorders;infertility due to hypogonadism  
         
    NAFARELIN Treatment of Endometriosis  
         
    NORETHISTERONE Contraception;treatment of Endometriosis,Menorrhagia,
Menopausal HRT,Premenstrual syndrome,treatment of breast cancer
 
         
    PROGESTERONE Dysfunctional Uterine bleeding;Amenorrhoea  
         
    TESTOSTERONE DERIVATIVES Dysfunctional Uterine bleeding;Amenorrhoea  
         
    TIBOLONE Treatment of menopausal vasomotor symptoms and prevention of post menopausal Osteoporosis  
         
    TRIPTORELIN Mgt of Endometriosis & Uterine Fibroids,mgt of femal infertility,mgt of precocious puberty Decopeptyl,Diphereline, Gonapeptyl,Trelstor
         
    UROFOLLITROPIN Female infertility/ Polycystic ovarian disease,in vitro fertilisation procedure,male infertility Bravelle,Fertinex, Follistim, Gonal -F
         
2. CORTICOSTEROIDS BETAMETHASONE Soft tissue inflammation  
         
    DEXAMETHASONE Antiemetic Dexacort
         
    HYDROCORTISONE ACETATE Replacement therapy in Adrenocortical insufficiency  
         
    PREDNISOLONE Suppression of allergic and inflammatory responses,bronchial asthama,severe dermatological reactions  
         
    TRIAMCINOLONE Replacement therapy in Adrenal insufficiency Kenolog,Aristocort, Nasacort, Tri-Nasal, Treiderm,Azmacort, Trilone,Volon A, Tricorlone, Triensence
         
3. TROPHIC HORMONES CHORIONIC GONADOTROPHIN Treatment of pre pubertal cryptorchidism,treatment of infertility due to hypogondotrophic hypogonadism;induction of ovulation and pregnency  
         
4. THYROIDS &ANTITHYROID DRUGS CARBIMAZOLE Mgt of Hyperthyroidism;preparation for thyroidectomy;adjunct to radio-iodine therapy;Grave's Disease  
         
    LEVOTHYROXINE Replacement therapy in treatment of Hypothyroidism;treatment of congenital Hypothyroidism,treatment of juvenile Myxoedema Thyrax, Evthyrox, Levaxin,L-thyroxine, Eltroxin,Thyrox, Evtirox, Levoxyl, Synthroid
         
5. GROWTH DISORDER BROMOCRIPTINE Adjunct to surgery and radiotherapy in patient w/ acromegaly Parlodel
         
    OCTREOTIDE Mgt of secretory neoplasms;treatment of acromegaly,prevention of complications following pancreatic surgery Sandostatin
         
    SOMATROPIN Treatment of growth Harmone defeciency;treatment of Turner's Syndrome,treatment of growth retardation due to chronic renal insufficiency  
         
6. VASOPRESSIN ANALOGUES DESMOPRESSIN Control of Cranial Diabetes insipidus;mgt of primary Nocturnal Enuresis DDAVP, Stimate,Minirin
         
    TERLIPRESSIN Intravenous;   Treatment of acute Oesphagal Variceal Haemorrhage Glypressin
         
    VASOPRESSIN Intravenous;   Initial control of Variceal Bleeding; treatment of Diabetes Insipidus Orgipressin, Anti Divretic

A. Corticosteroids:
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. Examples of Corticosteroids are as follows:

Brand Names Generic Prescription (Rx) Drugs

decadron

dexamethasone

deltasone,prednisone prednisolone

B. Gonadal Hormones & Related Drugs:
The male and female gonads produce steroid sex hormones, identical to those producted by adrenal cortical cells.
The male gonads known as the testes or testicles, secrete a class of hormones called androgens, and produce spermatozoa
The female gonads known as the ovaries, secrete the hormones estrogen and progesterone, as well as ova. Examples of Gonadal Hormones & Related Drugs are as follows. Various Drugs are as follows:

Brand Names Generic Prescription (Rx) Drugs

premarin

estrogens

aygestin norethindrone acetate
allyoestrenol allyloestrenol
danocrine danazol
provera,cycrin medroxyprogesterone

C. NSAIDs Antirheumatism:
Rheumatism or Rheumatic disorder is a non-specific term for medical problems affecting the heart, bones, joints, kidney, skin and lung. Examples of NSAIDs Antirheumatism are as follows.

Brand Names Generic Prescription (Rx) Drugs

feldene

piroxicam


D. Thyroid & Antithyroid:
The Thyroid is one of the largest endocrine glands in the body. The thyroid controls how quickly the body burns energy, makes proteins, and how sensitive the body should be to other hormones.The thyroid participates in these processes by producing thyroid hormones, principally thyroxine (T4) and triiodothyronine (T3). The diseases of Thyroid are treated with

An antithyroid agent is a hormone antagonist acting upon thyroid hormones. Examples of Antithyroids are as follows:

Brand Names Generic Prescription (Rx) Drugs

synthroid

levothyroxine

levothroid,synthroid levothyroxine