Pain is frequently the result of nociception activity in the nervous system that results from the stimulation of nociceptors. This activity is carried to the brain, usually via the spinal cord, and conveys information, without conscious awareness, about damage or near-damage in body tissues. Pain is the conscious experience of sensorial information and a feeling of unpleasantness that can manifest as a result of nociception. Neuropathic Pain differs from nociceptive Pain in that it involves damage to the nerve resulting in the sensation of Pain. There is also central Pain in which the Pain is generated in the brain from some form of lesion, and which is the most difficult for medical professionals to treat.

Pain, in the sense of physical Pain, is a typical sensory experience that may be described as the unpleasant awareness of a noxious stimulus or bodily harm. Individuals experience Pain by various daily hurts and aches, and sometimes through more serious injuries or illnesses. For scientific and clinical purposes, Pain is defined by the International Association for the Study of Pain (IASP) as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage".

In medicine, Pain is considered as highly subjective. A definition that is widely used in nursing was first given as early as 1968 by Margo McCaffery : "Pain is whatever the experiencing person says it is, existing whenever he says it does". Pain of any type is the most common reason for physician consultation in the United States, prompting half of all Americans to seek medical care annually. It is a major symptom in many medical conditions, significantly interfering with a person's quality of life and general functioning. Diagnosis is based on characterizing Pain in various ways, according to duration, intensity, type (dull, burning, throbbing or stabbing), source, or location in body. Usually Pain stops without treatment or responds to simple measures such as resting or taking an analgesic, and it is then called ‘acute’ Pain. But it may also become intractable and develop into a condition called chronic Pain, in which Pain is no longer considered a symptom but an illness by itself. The study of Pain has in recent years attracted many different fields such as pharmacology, neurobiology, nursing, dentistry, physiotherapy, and psychology. Pain medicine is a separate subspecialty figuring under some medical specialties like anesthesiology, physiatry, neurology, and psychiatry.

Pain is part of the body's defense system, triggering a reflex reaction to retract from a Painful stimulus, and helps adjust behavior to increase avoidance of that particular harmful situation in the future. Given its significance, physical Pain is also linked to various cultural, religious, philosophical, or social issues.

Fever
Fever is a frequent medical symptom that describes an increase in internal body temperature to levels above normal (the common oral measurement of normal human body temperature is 36.8±0.7 °C or 98.2±1.3 °F). Fever is most accurately characterized as a temporary elevation in the body's thermoregulatory set-point, usually by about 1–2°C. Fever differs from hyperthermia; hyperthermia is an increase in body temperature over the body's thermoregulatory set-point. Carl Wunderlich discovered that fever is not a disease but a symptom of disease.

A. Analgesics:
An analgesic is any member of the diverse group of drugs used to relieve Pain. Analgesic drugs act in various ways on the peripheral and central nervous systems.

Antipyretic: Antipyretics are drugs that reduce body temperature in situations such as fever. However, they will not affect the normal body temperature if one does not have fever.
Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever. Examples of Analgesics are as follows:

B.Antimigrane:
Antimigrane is used to treat Migraine which is a neurological syndrome that can cause a wide range of symptoms during an attack. The most commonly thought of symptom is headache. Examples of Antimigrane are as follows: